CLINICAL TRIALS AND OBSERVATIONS Autologous stem cell transplantation as a first-line treatment strategy for chronic lymphocytic leukemia: a multicenter, randomized, controlled trial from the SFGM-TC and GFLLC
نویسندگان
چکیده
Laurent Sutton,1 Sylvie Chevret,2 Olivier Tournilhac,3 Marine Diviné,4 Véronique Leblond,5 Bernadette Corront,6 Stéphane Leprêtre,7 Houchingue Eghbali,8 Eric Van Den Neste,9 Mauricette Michallet,10 Frédéric Maloisel,11 Krimo Bouabdallah,12 Didier Decaudin,13 Christian Berthou,14 Pauline Brice,15 Hugo Gonzalez,16 Elise Chapiro,17 Isabelle Radford-Weiss,18 Nathalie Leporrier,19 Karim Maloum,17 Florence Nguyen-Khac,17 Frédéric Davi,17 Julie Lejeune,2 Hélène Merle-Béral,17 and Michel Leporrier,20 for the Société Française de Greffe de Moelle et de Thérapie Cellulaire (SFGM-TC) and Groupe Français d’étude de la Leucémie Lymphoïde Chronique (GFLLC)
منابع مشابه
CLINICAL TRIALS AND OBSERVATIONS Autologous hematopoietic stem cell transplantation in chronic lymphocytic leukemia: results of European intergroup randomized trial comparing autografting versus observation
1Edouard Herriot Hospital, Lyon, France; 2University of Heidelberg, Heidelberg, Germany; 3Victor Dupouy Hospital, Argenteuil, France; 4EBMT Department of Medical Statistics, Leiden, The Netherlands; 5Clinical Trial Service Unit, Oxford, United Kingdom; 6Pitié Salpetrière Hospital, Paris, France; 7Centre hospitalier d’Annecy, Annecy, France; 8Royal Marsden Hospital, London, United Kingdom; 9Univ...
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BACKGROUND AND OBJECTIVE From the discovery of the Ph-chromosome, there has been an extraordinary progress in our understanding of chronic myeloid leukemia (CML). During the last three decades, new findings arising from dissection of the genetic abnormalities at a molecular level have received the most attention, but there have also been important new observations arising from studies of the bi...
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Donor lymphocyte infusions (DLIs) induce potent graft versus tumor (GVT) effects for relapsed chronic myelogenous leukemia (CML) after allogeneic stem cell transplantation (SCT) but are disappointing for other diseases. Disease resistance can occur if donor T cells are not appropriately activated in vivo. Ex vivo T-cell activation might overcome diseaseinduced anergy and augment GVT activity. W...
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